Lea has a background in wet-lab science and holds a PhD from ETH, Zürich in immunology. Since 2020 she is part of the IBU as a bioinformatics analyst.

Key Expertise:

  • Bulk RNA-seq Analysis
    • Design and implementation of end-to-end bulk RNA-seq workflows from pre-processing to advanced downstream interpretation.
  • ATAC-seq
    • Establishment and execution of ATAC-seq workflows.
  • Whole-Exome Sequencing (WES)
    • Analysis of WES datasets for variant calling, annotation, quality control, and interpretation, with experience in both germline and somatic pipelines.
  • Bisulfite-Sequencing
    • Processing and analysis of bisulfite-seq data for DNA methylation profiling.
  • Flow Cytometry & CyTOF
    • Processing, gating, and analysis of high-dimensional flow cytometry and CyTOF (mass cytometry) datasets, including panel design support, advanced clustering.
  • TotalSeq
    • Analysis of TotalSeq (CITE-seq) datasets integrating surface protein expression with single-cell transcriptomics, including pre-processing, normalization.
  • VDJ Sequencing & Multiomics
    • Processing and interpretation of TCR/BCR VDJ sequencing data, including clonotype identification, repertoire diversity analyses, and lineage tracking.
    • Integration of VDJ data with transcriptomic, proteomic (TotalSeq), and epigenomic datasets for comprehensive immune multiomics profiling.
  • Teaching & Training
    • Instructor for SIB: “When immunology meets bioinformatics”
    • Instructor for Omics: “Transcriptomics”