Differential methylation (DM) analysis

We use data from whole genome or reduced representation bisulfite sequencing to test for differential methylation between experimental groups. Our workflow relies on the nf-core methylseq pipeline to perform the alignment and methylation calling. This is followed by an in-house pipeline, which tests for differential methylation at the level of individual CpGs and larger genomic regions.


  • Documentation (download below)
  • Quality report and plots


Differential methylation analysis

  • Differentially methylated CpGs
  • Differentially methylated genomic regions


A zip archive containing the results from an example analysis can be downloaded below. Please refer to the included README and the documentation for more details.